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2308504-22-3

2308504-22-3 structure
2308504-22-3 structure
  • Name: JBI-589
  • Chemical Name: JBI-589
  • CAS Number: 2308504-22-3
  • Molecular Formula: C29H28FN5O
  • Molecular Weight: 481.56
  • Catalog: Research Areas Cancer
  • Create Date: 2023-09-22 15:53:03
  • Modify Date: 2024-01-11 20:08:39
  • JBI-589 is a non-covalent PAD4 isoform-selective inhibitor. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors[1].

Name JBI-589
Description JBI-589 is a non-covalent PAD4 isoform-selective inhibitor. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors[1].
Related Catalog
References

[1]. Deng H, et al. A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression. Cancer Res. 2022 Oct 4;82(19):3561-3572.  

[2]. Gajendran C, et al. Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4. Sci Rep. 2023 Feb 23;13(1):3189.  

Molecular Formula C29H28FN5O
Molecular Weight 481.56
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