JBI-589

Modify Date: 2024-01-11 20:08:39

JBI-589 Structure
JBI-589 structure
Common Name JBI-589
CAS Number 2308504-22-3 Molecular Weight 481.56
Density N/A Boiling Point N/A
Molecular Formula C29H28FN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JBI-589


JBI-589 is a non-covalent PAD4 isoform-selective inhibitor. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors[1].

 Names

Name JBI-589

 JBI-589 Biological Activity

Description JBI-589 is a non-covalent PAD4 isoform-selective inhibitor. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors[1].
Related Catalog
References

[1]. Deng H, et al. A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression. Cancer Res. 2022 Oct 4;82(19):3561-3572.  

[2]. Gajendran C, et al. Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4. Sci Rep. 2023 Feb 23;13(1):3189.  

 Chemical & Physical Properties

Molecular Formula C29H28FN5O
Molecular Weight 481.56