2828438-38-4

2828438-38-4 structure
2828438-38-4 structure
  • Name: LC-MB12
  • Chemical Name: LC-MB12
  • CAS Number: 2828438-38-4
  • Molecular Formula: C43H44Cl2N10O8
  • Molecular Weight: 899.78
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
  • Create Date: 2023-09-18 18:50:43
  • Modify Date: 2025-08-31 12:01:07
  • LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].

Name LC-MB12
Description LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].
Related Catalog
Target

FGFR2:11.8 nM (DC50)

References

[1]. Ma L, et al. Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. J Med Chem. 2023 Jun 8;66(11):7438-7453.  

Molecular Formula C43H44Cl2N10O8
Molecular Weight 899.78
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