2828438-38-4

2828438-38-4 structure

Name: LC-MB12
Chemical Name: LC-MB12
CAS Number: 2828438-38-4
Molecular Formula: C₄₃H₄₄Cl₂N₁₀O₈
Molecular Weight: 899.78
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2023-09-18 18:50:43
Modify Date: 2024-01-11 14:47:35
LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].

Name	LC-MB12

Description	LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Target	FGFR2:11.8 nM (DC50)
References	[1]. Ma L, et al. Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. J Med Chem. 2023 Jun 8;66(11):7438-7453.

Molecular Formula	C₄₃H₄₄Cl₂N₁₀O₈
Molecular Weight	899.78