LC-MB12

Modify Date: 2025-08-31 12:01:07

LC-MB12 Structure
LC-MB12 structure
Common Name LC-MB12
CAS Number 2828438-38-4 Molecular Weight 899.78
Density N/A Boiling Point N/A
Molecular Formula C43H44Cl2N10O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LC-MB12


LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].

 Names

Name LC-MB12

 LC-MB12 Biological Activity

Description LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].
Related Catalog
Target

FGFR2:11.8 nM (DC50)

References

[1]. Ma L, et al. Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer. J Med Chem. 2023 Jun 8;66(11):7438-7453.  

 Chemical & Physical Properties

Molecular Formula C43H44Cl2N10O8
Molecular Weight 899.78
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