2927489-99-2
2927489-99-2 structure
- Name: MAO A/HSP90-IN-2
- Chemical Name: MAO A/HSP90-IN-2
- CAS Number: 2927489-99-2
- Molecular Formula: C25H31ClN2O4
- Molecular Weight: 458.98
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2023-10-12 10:03:13
- Modify Date: 2024-01-12 18:55:42
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MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].
| Name | MAO A/HSP90-IN-2 |
|---|
| Description | MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1]. |
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| Related Catalog | |
| Target |
MAO-A:4.58 μM (IC50) HSP90:0.016 μM (IC50) |
| References |
| Molecular Formula | C25H31ClN2O4 |
|---|---|
| Molecular Weight | 458.98 |