MAO A/HSP90-IN-2

Modify Date: 2025-08-25 17:47:17

MAO A/HSP90-IN-2 Structure
MAO A/HSP90-IN-2 structure
 Common Name MAO A/HSP90-IN-2
CAS Number 2927489-99-2 Molecular Weight 458.98
Density N/A Boiling Point N/A
Molecular Formula C25H31ClN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MAO A/HSP90-IN-2


MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].

 Names

Name MAO A/HSP90-IN-2

 MAO A/HSP90-IN-2 Biological Activity

Description MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide (HY-17364) -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].
Related Catalog
Target

MAO-A:4.58 μM (IC50)

HSP90:0.016 μM (IC50)

References

[1]. 1、Hui-Ju Tseng, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. European Journal of Medicinal Chemistry. Volume 256, 5 August 2023, 115459.

[2]. Hui-Ju Tseng, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. European Journal of Medicinal Chemistry. Volume 256, 5 August 2023, 115459.  

 Chemical & Physical Properties

Molecular Formula C25H31ClN2O4
Molecular Weight 458.98
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Chemsrc provides MAO A/HSP90-IN-2(CAS#:2927489-99-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MAO A/HSP90-IN-2 are included as well.>> amp version: MAO A/HSP90-IN-2

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