2767204-39-5

2767204-39-5 structure

Name: PROTAC BTK Degrader-6
Chemical Name: PROTAC BTK Degrader-6
CAS Number: 2767204-39-5
Molecular Formula: C₄₅H₄₇N₁₁O₆
Molecular Weight: 837.92
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2023-09-21 14:42:12
Modify Date: 2024-01-13 18:18:56
PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6)[1].

Name	PROTAC BTK Degrader-6

Description	PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC
Target	3.18 nM (BTK)[1]
References	[1]. Huang J, et al. Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation. Eur J Med Chem. 2023 Jul 18;259:115664.

Molecular Formula	C₄₅H₄₇N₁₁O₆
Molecular Weight	837.92