2911646-14-3

2911646-14-3 structure

Name: A09-003
Chemical Name: A09-003
CAS Number: 2911646-14-3
Molecular Formula: C₂₃H₂₆N₄O
Molecular Weight: 374.48
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2024-04-06 17:14:28
Modify Date: 2024-04-06 17:14:28
A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].

Name	A09-003

Description	A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Mcl-1
References	[1]. Sim KM, et al. A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein. Chem Biol Interact. 2023 Sep 1;382:110554.

Molecular Formula	C₂₃H₂₆N₄O
Molecular Weight	374.48