A09-003

Modify Date: 2024-04-06 17:14:28

A09-003 structure	Common Name	A09-003
	CAS Number	2911646-14-3	Molecular Weight	374.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₆N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of A09-003

A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].

Name	A09-003

Description	A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Mcl-1
References	[1]. Sim KM, et al. A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein. Chem Biol Interact. 2023 Sep 1;382:110554.

Molecular Formula	C₂₃H₂₆N₄O
Molecular Weight	374.48

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: A09-003
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Purity: 99.84%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.