1448355-15-4

1448355-15-4 structure

Name: HL23
Chemical Name: HL23
CAS Number: 1448355-15-4
Molecular Formula: C₄₄H₄₄N₂O₇
Molecular Weight: 712.83
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2024-09-23 12:17:34
Modify Date: 2024-09-23 12:17:34
HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221)[1].

Name	HL23

Description	HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Lu Y, et al. Thioredoxin-interacting protein-activated intracellular potassium deprivation mediates the anti-tumour effect of a novel histone acetylation inhibitor HL23, a fangchinoline derivative, in human hepatocellular carcinoma. J Adv Res. 2023 Sep;51:181-196.. .

Molecular Formula	C₄₄H₄₄N₂O₇
Molecular Weight	712.83