HL23
Modify Date: 2024-09-23 12:17:34
HL23 structure
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Common Name | HL23 | ||
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| CAS Number | 1448355-15-4 | Molecular Weight | 712.83 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H44N2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HL23HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221)[1]. |
| Name | HL23 |
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| Description | HL23 is a histone deacetylase (HDAC) inhibitor with activity against hepatocellular carcinoma (HCC). HL23 enhances acetylation of the TXNIP promoter and upregulates TXNIP expression, thereby mediating potassium channel activity and triggering TXNIP-dependent potassium deprivation. HL23 inhibits HCC progression and metastasis and has a synergistic effect with Sorafenib (HY-10201) and is more potent than Sorafenib+Vorinostat (HY-10221)[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C44H44N2O7 |
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| Molecular Weight | 712.83 |