2238820-43-2

2238820-43-2 structure

Name: JT002
Chemical Name: JT002
CAS Number: 2238820-43-2
Molecular Formula: C₂₀H₂₄N₄O₅S
Molecular Weight: 432.49
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2023-10-30 10:51:30
Modify Date: 2025-08-25 16:08:48
JT002 is an orally active inhibitor of the NLRP3 inflammasome. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice[1].

Name	JT002

Description	JT002 is an orally active inhibitor of the NLRP3 inflammasome. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
References	[1]. Ambrus-Aikelin G, et al. JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep. 2023 Aug 19;13(1):13524.

Molecular Formula	C₂₀H₂₄N₄O₅S
Molecular Weight	432.49