412328-25-7

412328-25-7 structure

Name: Lepadin H
Chemical Name: Lepadin H
CAS Number: 412328-25-7
Molecular Formula: C₂₆H₄₅NO₃
Molecular Weight: 419.64
Catalog: Signaling Pathways Apoptosis Ferroptosis
Create Date: 2024-09-15 20:58:08
Modify Date: 2025-08-25 13:36:31
Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].

Name	Lepadin H

Description	Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Apoptosis >> Ferroptosis
References	[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.

Molecular Formula	C₂₆H₄₅NO₃
Molecular Weight	419.64