Lepadin H

Modify Date: 2025-08-25 13:36:31

Lepadin H Structure
Lepadin H structure
Common Name Lepadin H
CAS Number 412328-25-7 Molecular Weight 419.64
Density N/A Boiling Point N/A
Molecular Formula C26H45NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lepadin H


Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].

 Names

Name Lepadin H

 Lepadin H Biological Activity

Description Lepadin H is a marine alkaloid and ferroptosis inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway[1].
Related Catalog
References

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215.  

 Chemical & Physical Properties

Molecular Formula C26H45NO3
Molecular Weight 419.64
InChIKey RLTXIRPCJHXWEP-AFEGZDPGSA-N
SMILES CCCC=CC=CC(=O)OC1CC2C(CCCCC(O)CCC)CCCC2NC1C
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