2319939-24-5

2319939-24-5 structure

Name: (S)-CCG-1423
Chemical Name: (S)-CCG-1423
CAS Number: 2319939-24-5
Molecular Formula: C₁₈H₁₃ClF₆N₂O₃
Molecular Weight: 454.75
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2023-12-01 21:57:26
Modify Date: 2024-01-07 19:16:06
(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].

Name	(S)-CCG-1423

Description	(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Signaling Pathways >> GPCR/G Protein >> Ras Research Areas >> Metabolic Disease
References	[1]. Watanabe B, et al. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10(8):e0136242.

Molecular Formula	C₁₈H₁₃ClF₆N₂O₃
Molecular Weight	454.75