(S)-CCG-1423

Modify Date: 2024-01-07 19:16:06

(S)-CCG-1423 Structure
(S)-CCG-1423 structure
Common Name (S)-CCG-1423
CAS Number 2319939-24-5 Molecular Weight 454.75
Density N/A Boiling Point N/A
Molecular Formula C18H13ClF6N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S)-CCG-1423


(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].

 Names

Name (S)-CCG-1423

 (S)-CCG-1423 Biological Activity

Description (S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].
Related Catalog
References

[1]. Watanabe B, et al. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10(8):e0136242.  

 Chemical & Physical Properties

Molecular Formula C18H13ClF6N2O3
Molecular Weight 454.75
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