2714434-21-4

2714434-21-4 structure

Name: YAP-TEAD-IN-3
Chemical Name: YAP-TEAD-IN-3
CAS Number: 2714434-21-4
Molecular Formula: C₂₇H₂₆ClF₂N₃O₄
Molecular Weight: 529.96
Catalog: Signaling Pathways Stem Cell/Wnt YAP
Create Date: 2023-10-26 20:33:04
Modify Date: 2026-10-11 22:36:28
YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. YAP-TEAD-IN-3 inhibits Avi-humanTEAD4217-434 with an IC50 value of 9 nM. YAP-TEAD-IN-3 also inhibits NCI-H2052 with an GI50 of 0.048 μM (cell proliferation)，and an IC50 of 0.048 μM (YAP reporter gene expression)，respsectively[1].

Name	YAP-TEAD-IN-3
Synonyms	3-Pyridinecboxamide, 4-[(2S)-5-chloro-6-fluoro-2,3-dihydro-2-phenyl-2-(2S)-2-pyrrolidinyl-4-benzofuranyl]-5-fluoro-6-(2-hydroxyethoxy)-N-methyl-, (4S) IAG933 4-(5-Chloro-6-fluoro-2-phenyl-2-(pyrrolidin-2-yl)-2,3-dihydrobenzofuran-4-yl)-5-fluoro-6-(2-hydroxyethoxy)-N-methylnicotinamide

Description	YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. YAP-TEAD-IN-3 inhibits Avi-humanTEAD4217-434 with an IC50 value of 9 nM. YAP-TEAD-IN-3 also inhibits NCI-H2052 with an GI50 of 0.048 μM (cell proliferation)，and an IC50 of 0.048 μM (YAP reporter gene expression)，respsectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> YAP
Target	IC50: 9 nM (YAP-TEAD)[1]
References	[1]. Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.

Molecular Formula	C₂₇H₂₆ClF₂N₃O₄
Molecular Weight	529.96