2952994-34-0

2952994-34-0 structure

Name: YXG-158
Chemical Name: YXG-158
CAS Number: 2952994-34-0
Molecular Formula: C₃₀H₃₆FN₃O
Molecular Weight: 473.62
Catalog: Research Areas Cancer
Create Date: 2023-11-02 08:29:51
Modify Date: 2024-01-03 14:05:18
YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].

Name	YXG-158

Description	YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
Target	DC50: 1.28 μM (androgen receptor)[1]. IC50: 100 nM (CYP17A1)[1].
References	[1]. Wang A, et al. Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2023 Jul 27;66(14):9972-9991.

Molecular Formula	C₃₀H₃₆FN₃O
Molecular Weight	473.62