YXG-158

Modify Date: 2024-01-03 14:05:18

YXG-158 structure	Common Name	YXG-158
	CAS Number	2952994-34-0	Molecular Weight	473.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₆FN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of YXG-158

YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].

Name	YXG-158

Description	YXG-158 (Compound 23-h) is an orally active AR degrader and CYP17A1 inhibitor. YXG-158 has AR degradation activity with DC50 value of 1.28 μM. YXG-158 can inhibit CYP17A1 with IC50 value of 100 nM. XG-158 can be used for the research of enzalutamide-resistant prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
Target	DC50: 1.28 μM (androgen receptor)[1]. IC50: 100 nM (CYP17A1)[1].
References	[1]. Wang A, et al. Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer. J Med Chem. 2023 Jul 27;66(14):9972-9991.

Molecular Formula	C₃₀H₃₆FN₃O
Molecular Weight	473.62

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YXG-158

Use of YXG-158

Names

YXG-158 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.