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Product Name: SALSOLIDINE
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493-48-1

493-48-1 structure

493-48-1 structure

Name: (S)-Salsolidine
Chemical Name: salsolidine
CAS Number: 493-48-1
Molecular Formula: C₁₂H₁₇NO₂
Molecular Weight: 207.27
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2018-07-20 09:30:57
Modify Date: 2026-07-22 13:31:36
(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM)[1].

Name	salsolidine
Synonyms	(s)-salsolidine (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methylisoquinoline (±)-Salsolidine rac-salsolidine 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-isoquinolin SALSOLIDINE (R)-1-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline rac-1α*-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin 2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-(s)-isoquinolin (1S)-6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline Salsolindine (S)-4-bromo-3-(pent-4-en-2-yloxy)benzonitrile salsolidin (1S)-1,2,3,4-Tetrahydro-1-methyl-6,7-dimethoxyisoquinoline (R)-(+)-Salsolidine Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, (1S) (R)-Salsolidine 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

Description	(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (Ki=63 μM). The R enantiomer of Salsolidine is more potent than the S form (Ki=26 μM)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	Salsolidine is a dopamine-derived tetrahydroisoquinoline-alkaloid which possesses an asymmetric center at C-1 and exists as R and S enantiomers[1].
References	[1]. Dostert P, et al. Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J Neural Transm. 1988;74(2):61-74.

Density	1.034g/cm3
Boiling Point	313.4ºC at 760mmHg
Molecular Formula	C₁₂H₁₇NO₂
Molecular Weight	207.27
Flash Point	127.1ºC
Exact Mass	207.12600
PSA	30.49000
LogP	2.23930
Vapour Pressure	0.000496mmHg at 25°C
Index of Refraction	1.509

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NX5018500

CHEMICAL NAME :: Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-

CAS REGISTRY NUMBER :: 493-48-1

LAST UPDATED :: 199312

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H17-N-O2

MOLECULAR WEIGHT :: 207.30

WISWESSER LINE NOTATION :: T66 CMT&J B1 HO1 IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,249,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 15(2),54,1981

Precursor 0
DownStream 4
4721-98-6 493-48-1 38221-21-5 525-72-4

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