493-48-1

• 常用中文名：猪毛菜定
• 常用英文名：(S)-Salsolidine
• CAS号：493-48-1
• 分子式：C₁₂H₁₇NO₂
• 分子量：207.27
• 相关类别： 信号通路 神经信号通路 单胺氧化酶
• 发布时间：2018-07-20 09:30:57
• 更新时间：2026-07-22 13:31:36
• (S) -莎索利多胺是一种弱单胺氧化酶(MAO)抑制剂(Ki=63μM)。沙索利多胺的R对映体比S型更有效(Ki=26μM)[1]。

名称

• 中文名: 猪毛菜定
• 英文名: salsolidine
• 中文别名: 6,7-二甲氧基-1-甲基-1,2,3,4-四氢异喹啉(SALSOLIDINE); 鹿尾草定
• 英文别名: (s)-salsolidine; (S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methylisoquinoline; (±)-Salsolidine; rac-salsolidine; 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-isoquinolin; SALSOLIDINE; (R)-1-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; rac-1α*-Methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinolin; 2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-(s)-isoquinolin; (1S)-6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline; Salsolindine; (S)-4-bromo-3-(pent-4-en-2-yloxy)benzonitrile; salsolidin; (1S)-1,2,3,4-Tetrahydro-1-methyl-6,7-dimethoxyisoquinoline; (R)-(+)-Salsolidine; Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl-, (1S); (R)-Salsolidine; 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline; 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline; 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

物化性质

• 密度: 1.034g/cm3
• 沸点: 313.4ºC at 760mmHg
• 分子式: C₁₂H₁₇NO₂
• 分子量: 207.27
• 闪点: 127.1ºC
• 精确质量: 207.12600
• PSA: 30.49000
• LogP: 2.23930
• 蒸汽压: 0.000496mmHg at 25°C
• 折射率: 1.509

生物活性

• 描述: (S) -莎索利多胺是一种弱单胺氧化酶(MAO)抑制剂(Ki=63μM)。沙索利多胺的R对映体比S型更有效(Ki=26μM)[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  研究领域 >> 神经疾病
• 靶点:

  Human Endogenous Metabolite

• 体外研究: Salsolidine是一种多巴胺衍生的四氢异喹啉生物碱,在C-1上具有不对称中心,以R和S对映体的形式存在[1]。
• 参考文献:

  [1]. Dostert P, et al. Dopamine-derived alkaloids in alcoholism and in Parkinson's and Huntington's diseases. J Neural Transm. 1988;74(2):61-74.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NX5018500 CHEMICAL NAME : Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methyl- CAS REGISTRY NUMBER : 493-48-1 LAST UPDATED : 199312 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H17-N-O2 MOLECULAR WEIGHT : 207.30 WISWESSER LINE NOTATION : T66 CMT&J B1 HO1 IO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 41,249,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 15(2),54,1981

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