1620107-33-6

1620107-33-6 structure

Name: LU-005i
Chemical Name: L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-N-[(1S)-1-(cyclohexylmethyl)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl]-O-methyl-
CAS Number: 1620107-33-6
Molecular Formula: C₃₁H₄₆N₄O₇
Molecular Weight: 586.72
Catalog: Research Areas Inflammation/Immunology
Create Date: 2024-03-15 14:50:29
Modify Date: 2024-03-15 14:50:29
LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].

Name	L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-N-[(1S)-1-(cyclohexylmethyl)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl]-O-methyl-

Description	LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	β5i subunit of immunoproteasomes (IC50 = 6.6 nM), β5c subunit of immunoproteasomes (IC50 = 287 nM)[1]
References	[1]. Rezvan Moallemian, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.Biochem Pharmacol. 2020 Jul:177:113964.