2447607-85-2

2447607-85-2 structure

Name: ALK-IN-26
Chemical Name: ALK-IN-26
CAS Number: 2447607-85-2
Molecular Formula: C₂₄H₂₃NO₃S
Molecular Weight: 405.51
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2023-12-26 17:34:59
Modify Date: 2024-01-18 21:09:53
ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase. ALK-IN-26 has good pharmacokinetic properties and blood-brain barrier (BBB) permeability. ALK-IN-26 can induce apoptosis, autophagy and necrosis. ALK-IN-26 can be used in glioblastoma studies[1].

Name	ALK-IN-26

Description	ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase. ALK-IN-26 has good pharmacokinetic properties and blood-brain barrier (BBB) permeability. ALK-IN-26 can induce apoptosis, autophagy and necrosis. ALK-IN-26 can be used in glioblastoma studies[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Feng L, et al. Synthesis and Bioevaluation of 3-(Arylmethylene) indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities[J]. Journal of Medicinal Chemistry, 2023.