167838-64-4

167838-64-4 structure

Name: FR173657
Chemical Name: FR173657
CAS Number: 167838-64-4
Molecular Formula: C₃₀H₂₇Cl₂N₅O₄
Molecular Weight: 592.47
Catalog: Signaling Pathways GPCR/G Protein Bradykinin Receptor
Create Date: 2023-12-31 22:18:06
Modify Date: 2024-01-31 09:43:48
FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].

Name	FR173657

Description	FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
Target	0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively[1]
References	[1]. Asano M, et al. The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657. Br J Pharmacol. 1997 Feb;120(4):617-24.

Molecular Formula	C₃₀H₂₇Cl₂N₅O₄
Molecular Weight	592.47