FR173657
Modify Date: 2025-10-11 20:09:03
FR173657 structure
|
Common Name | FR173657 | ||
|---|---|---|---|---|
| CAS Number | 167838-64-4 | Molecular Weight | 592.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H27Cl2N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FR173657FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1]. |
| Name | FR173657 |
|---|
| Description | FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1]. |
|---|---|
| Related Catalog | |
| Target |
0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively[1] |
| References |
| Molecular Formula | C30H27Cl2N5O4 |
|---|---|
| Molecular Weight | 592.47 |
| InChIKey | XCKWRUGRUFVXGC-NTEUORMPSA-N |
| SMILES | CC(=O)Nc1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 |