2766575-48-6

2766575-48-6 structure

Name: SWTX-143
Chemical Name: SWTX-143
CAS Number: 2766575-48-6
Molecular Formula: C₁₉H₁₈F₃N₃O
Molecular Weight: 361.36
Catalog: Signaling Pathways Stem Cell/Wnt YAP
Create Date: 2023-12-21 17:38:00
Modify Date: 2024-01-08 08:52:17
SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].

Name	SWTX-143

Description	SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> YAP
References	[1]. Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.

Molecular Formula	C₁₉H₁₈F₃N₃O
Molecular Weight	361.36