SWTX-143

Modify Date: 2024-01-08 08:52:17

SWTX-143 Structure
SWTX-143 structure
Common Name SWTX-143
CAS Number 2766575-48-6 Molecular Weight 361.36
Density N/A Boiling Point N/A
Molecular Formula C19H18F3N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SWTX-143


SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].

 Names

Name SWTX-143

 SWTX-143 Biological Activity

Description SWTX-143 is a novel covalent YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity[1].
Related Catalog
References

[1]. Hanne Hillen, et al. A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models. Mol Cancer Ther. 2023 Sep 23.  

 Chemical & Physical Properties

Molecular Formula C19H18F3N3O
Molecular Weight 361.36
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