1005178-02-8

1005178-02-8 structure

Name: TI17
Chemical Name: TI17
CAS Number: 1005178-02-8
Molecular Formula: C₂₃H₂₂N₂O₃
Molecular Weight: 374.43
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-01-20 18:40:40
Modify Date: 2024-01-20 18:40:40
TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].

Name	TI17

Description	TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Others >> Thyroid Hormone Receptor
Target	Thyroid hormone receptor interacting protein 13 (Trip13)[1]
References	[1]. Chang S et al. TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage. Cancer Med. 2023 Nov 9.

Molecular Formula	C₂₃H₂₂N₂O₃
Molecular Weight	374.43