1005178-02-8

1005178-02-8 structure
1005178-02-8 structure
  • Name: TI17
  • Chemical Name: TI17
  • CAS Number: 1005178-02-8
  • Molecular Formula: C23H22N2O3
  • Molecular Weight: 374.43
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2024-01-20 18:40:40
  • Modify Date: 2024-01-20 18:40:40
  • TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].

Name TI17
Description TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].
Related Catalog
Target

Thyroid hormone receptor interacting protein 13 (Trip13)[1]

References

[1]. Chang S et al. TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage. Cancer Med. 2023 Nov 9.  

Molecular Formula C23H22N2O3
Molecular Weight 374.43
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