437655-95-3

437655-95-3 structure

Name: Fmoc-NH-PEG4-CH2COOH
Chemical Name: 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18 -oic acid
CAS Number: 437655-95-3
Molecular Formula: C₂₅H₃₁NO₈
Molecular Weight: 473.51600
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2016-08-31 11:49:54
Modify Date: 2024-01-06 18:14:17
Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18 -oic acid
Synonyms	14-methylpentadecyl bromide 14-morpholin-4-yl-daunomycin 14-Morpholino-daunomycin 14-methyl-1-bromopentadecane Pentadecane,1-bromo-14-methyl

Description	Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Maggie Lu, et al. Linker-wirkstoff und antikörper-wirkstoff-konjugat (adc) damit. EP3335734A1.

Molecular Formula	C₂₅H₃₁NO₈
Molecular Weight	473.51600
Exact Mass	473.20500
PSA	116.04000
LogP	2.88050
Storage condition	2-8°C

894427-95-3

~65%

437655-95-3

Literature: N.V. ORGANON Patent: WO2007/42469 A2, 2007 ; Location in patent: Page/Page column 15; 16 ;

195071-49-9

28920-43-6

~63%

437655-95-3

Literature: Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180