437655-95-3

437655-95-3 structure

Name: Fmoc-NH-PEG4-CH2COOH
Chemical Name: 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18 -oic acid
CAS Number: 437655-95-3
Molecular Formula: C₂₅H₃₁NO₈
Molecular Weight: 473.51600
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2016-08-31 11:49:54
Modify Date: 2026-07-16 14:37:19
Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18 -oic acid
Synonyms	Fmoc-NH-PEG4-CH2CO2H 2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid [2-(2-{2-[2-((9H-fluoren-9-yl-methoxycbonyl)amino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid Fmoc-PEG4-acetic acid 14-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,6,9,12-tetraoxatetradecanoic acid 14-[(9-Fluorenylmethoxycbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid 1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester Fmoc-N-Amido-PEG4-CH2COOH 14-Morpholino-daunomycin Fmoc-NH-PEG5-CH2CO2H Fmoc-PEG4- CH2COOH 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid FmocNH-PEG4-CH2COOH/5,8,11,14-Tetraoxa-2-azahexadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester 14-methyl-1-bromopentadecane Pentadecane,1-bromo-14-methyl FMoc-NH-PEG4-CH2COOH 14-morpholin-4-yl-daunomycin 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Fmoc-N-amido-PEG4-acetic acid 14-methylpentadecyl bromide

Description	Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Maggie Lu, et al. Linker-wirkstoff und antikörper-wirkstoff-konjugat (adc) damit. EP3335734A1.

Molecular Formula	C₂₅H₃₁NO₈
Molecular Weight	473.51600
Exact Mass	473.20500
PSA	116.04000
LogP	2.88050
Storage condition	2-8°C

894427-95-3

~65%

437655-95-3

Literature: N.V. ORGANON Patent: WO2007/42469 A2, 2007 ; Location in patent: Page/Page column 15; 16 ;

195071-49-9

28920-43-6

~63%

437655-95-3

Literature: Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P. Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180

112-60-7

437655-95-3

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

77544-60-6

437655-95-3

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

86770-74-3

437655-95-3

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

86770-67-4

437655-95-3

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

106984-09-2

437655-95-3

Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48

Precursor 7
195071-49-9 28920-43-6 112-60-7 77544-60-6
86770-74-3 86770-67-4 106984-09-2
DownStream 0

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