77544-60-6
77544-60-6 structure
- Name: Tetraethylene glycol monotosylate
- Chemical Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
- CAS Number: 77544-60-6
- Molecular Formula: C15H24O7S
- Molecular Weight: 348.41200
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-04-17 08:00:00
- Modify Date: 2026-06-30 15:28:25
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Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol |
|---|---|
| Synonyms |
HO-PEG4-OTS
Monotosylated tetraethylene glycol 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl p-Toluenesul Tos-PEG4-OH 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-1-tosylethanol Tetraethylene glycol p-toluenesulfonate 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylate tetraethyleneglycol monotosylate [2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate Tetraethylene glycol tosylate Ts-tetraglycol 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl) 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate tetraglycol-Ts Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,4-methylbenzenesulfonate Tos-PEG4 Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-Methylbenzenesulfonate) OH-PEG4-Tos Tos-PEG4-OH/Ethanol, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate) Hydroxy-PEG5-Tos toluene-4-sulfonic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester p-Toluenesulfonic Acid 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl Ester 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate HO-(CH2CH2O)4-Tos PEG5-Tos Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,1-(4-Methylbenzenesulfonate) 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate PEG5-Tosylate |
| Description | Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Molecular Formula | C15H24O7S |
|---|---|
| Molecular Weight | 348.41200 |
| Exact Mass | 348.12400 |
| PSA | 110.67000 |
| LogP | 1.21000 |
| Symbol |
GHS05, GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H314 |
| Precautionary Statements | P280-P301 + P310-P305 + P351 + P338-P310 |
| RIDADR | UN 2927 8(6.1) / PGII |
| HS Code | 2909499000 |
| Flash Point(F) | >230 °F |
| Flash Point(C) | >110 °C |
|
~98%
77544-60-6 |
| Literature: Park, Ki Duk; Liu, Rihe; Kohn, Harold Chemistry and Biology, 2009 , vol. 16, # 7 p. 763 - 772 |
|
~85%
77544-60-6 |
| Literature: Organic Letters, , vol. 4, # 14 p. 2329 - 2332 |
|
~81%
77544-60-6 |
| Literature: Percec, Virgil; Leowanawat, Pawaret; Sun, Hao-Jan; Kulikov, Oleg; Nusbaum, Christopher D.; Tran, Tam M.; Bertin, Annabelle; Wilson, Daniela A.; Peterca, Mihai; Zhang, Shaodong; Kamat, Neha P.; Vargo, Kevin; Moock, Diana; Johnston, Eric D.; Hammer, Daniel A.; Pochan, Darrin J.; Chen, Yingchao; Chabre, Yoann M.; Shiao, Tze C.; Bergeron-Brlek, Milan; Andre, Sabine; Roy, Rene; Gabius, Hans-J.; Heiney, Paul A. Journal of the American Chemical Society, 2013 , vol. 135, # 24 p. 9055 - 9077 |
| Precursor 3 | |
|---|---|
| DownStream 10 | |
![2-[2-[2-(2-phenoxyethoxy)ethoxy]ethoxy]ethanol structure](https://image.chemsrc.com/caspic/175/36366-93-5.png)
![2-[2-[2-(2-iodoethoxy)ethoxy]ethoxy]ethanol structure](https://image.chemsrc.com/caspic/268/136399-06-9.png)
![2-[2-[2-(2-quinolin-8-yloxyethoxy)ethoxy]ethoxy]ethanol structure](https://image.chemsrc.com/caspic/405/77544-61-7.png)
| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |