Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

77544-60-6

77544-60-6 structure

Name: Tetraethylene glycol monotosylate
Chemical Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
CAS Number: 77544-60-6
Molecular Formula: C₁₅H₂₄O₇S
Molecular Weight: 348.41200
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-04-17 08:00:00
Modify Date: 2025-08-27 17:02:10
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
Synonyms	toluene-4-sulfonic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester tetraglycol-Ts Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,1-(4-Methylbenzenesulfonate) [2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate Ts-tetraglycol tetraethyleneglycol monotosylate

Description	Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Park KD, et al. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.Chem Biol. 2009 Jul 31;16(7):763-72.

Molecular Formula	C₁₅H₂₄O₇S
Molecular Weight	348.41200
Exact Mass	348.12400
PSA	110.67000
LogP	1.21000

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H301-H314
Precautionary Statements	P280-P301 + P310-P305 + P351 + P338-P310
RIDADR	UN 2927 8(6.1) / PGII
HS Code	2909499000
Flash Point(F)	>230 °F
Flash Point(C)	>110 °C

112-60-7

98-59-9

~98%

77544-60-6

Literature: Park, Ki Duk; Liu, Rihe; Kohn, Harold Chemistry and Biology, 2009 , vol. 16, # 7 p. 763 - 772

112-60-7

98-59-9

~85%

37860-51-8

77544-60-6

Literature: Organic Letters, , vol. 4, # 14 p. 2329 - 2332

112-60-7

104-15-4

~81%

77544-60-6

Literature: Percec, Virgil; Leowanawat, Pawaret; Sun, Hao-Jan; Kulikov, Oleg; Nusbaum, Christopher D.; Tran, Tam M.; Bertin, Annabelle; Wilson, Daniela A.; Peterca, Mihai; Zhang, Shaodong; Kamat, Neha P.; Vargo, Kevin; Moock, Diana; Johnston, Eric D.; Hammer, Daniel A.; Pochan, Darrin J.; Chen, Yingchao; Chabre, Yoann M.; Shiao, Tze C.; Bergeron-Brlek, Milan; Andre, Sabine; Roy, Rene; Gabius, Hans-J.; Heiney, Paul A. Journal of the American Chemical Society, 2013 , vol. 135, # 24 p. 9055 - 9077

Precursor 3
112-60-7 98-59-9 104-15-4
DownStream 10
86770-74-3 86770-67-4 106984-09-2 134179-38-7
36366-93-5 136399-06-9 168640-82-2 77544-61-7
90952-27-5 437655-95-3

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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