173388-20-0

173388-20-0 structure

Name: TEI-9647
Chemical Name: (1S,3R,5Z,7E,23S)-1,3-Dihydroxy-23,26-epoxy-9,10-secocholesta-5,7 ,10,25(27)-tetraen-26-one
CAS Number: 173388-20-0
Molecular Formula: C₂₇H₃₈O₄
Molecular Weight: 426.58800
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2017-09-04 05:00:32
Modify Date: 2024-01-13 17:53:43
TEI-9647 is a first and potent VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist. TEI-9647 is a 1α,25-dihydroxyvitamin D3-26,23-lactone (1α,25-lactone) analogue[1].

Name	(1S,3R,5Z,7E,23S)-1,3-Dihydroxy-23,26-epoxy-9,10-secocholesta-5,7 ,10,25(27)-tetraen-26-one

Description	TEI-9647 is a first and potent VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist. TEI-9647 is a 1α,25-dihydroxyvitamin D3-26,23-lactone (1α,25-lactone) analogue[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Metabolic Disease
Target	VDR[1]
In Vitro	TEI-9647 (100 nM; 24 hours; HL-60 cells) treatment clearly suppresses p21WAF1,CIP1 gene expression induced by 1α,25(OH)2D3[1]. TEI-9647 blocks both 1α,25(OH)2D3-mediated HL-60 cell differentiation and also activation of the luciferase reporter in COS-7 cells that has been transfected with the cDNA containing the DRE of the rat 25(OH)D3-24-hydroxylase gene and cDNA of the human vitamin D nuclear receptor[1]. RT-PCR[1] Cell Line: HL-60 cells Concentration: 100 nM Incubation Time: 24 hours Result: Clearly suppressed p21WAF1,CIP1 gene expression induced by 1α,25(OH)2D3.
References	[1]. Miura D, et al. Antagonistic action of novel 1alpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1alpha,25-dihydroxyvitamin D3. J Biol Chem. 1999 Jun 4;274(23):16392-9.