156951-82-5

156951-82-5 structure

Name: Chrysotoxine
Chemical Name: 4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol
CAS Number: 156951-82-5
Molecular Formula: C₁₈H₂₂O₅
Molecular Weight: 318.36
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-03-25 21:20:23
Modify Date: 2025-09-23 19:24:59
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].

Name	4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxyphenol
Synonyms	Phenol,4-[2-(3,4-dimethoxyphenyl)ethyl]-2,6-dimethoxy

Description	Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> PI3K/Akt/mTOR >> Akt
References	[1]. Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346. [2]. Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.