Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tenofovir Alafenamide Hemifumarate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

1392275-56-7

1392275-56-7 structure

Name: Tenofovir Alafenamide Hemifumarate
Chemical Name: Tenofovir Alafenamide Hemifumarate
CAS Number: 1392275-56-7
Molecular Formula: C₄₆H₆₂N₁₂O₁₄P₂
Molecular Weight: 1069.0
Catalog: API Synthetic anti-infective drugs Antiviral drugs
Create Date: 2018-09-25 18:31:14
Modify Date: 2026-06-30 12:06:37
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

Name	Tenofovir Alafenamide Hemifumarate
Synonyms	Anti-HIV Isopropyl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate (2E)-2-butenedioate (2:1) GS-7340 Hemifumarate TAF(Tenofovir Alafenamide Hemifumate) 3H-1,2,4-Triazole-3-thione,4-amino-2,4-dihydro-5-(10-methoxyphenyl) Tenofovir Alafenamide Hemifumate salt Tenofovir Alafenamide Hemifumate(2:1) TENOFOVIR ALAFENAMIDE HEMIFUMATE (GS-7340 HEMIFUMATE) Tenofovir alafenamide hemifumate (GS-7340) L-Alanine, N-[(S)-[(1S)-[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1) enofovir Alafenamide Fumarate (R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumate Tenofovir Alafenamide Fumate //BP (Tenofovir alafenamide : fumate = 2:1) GS-7340 (hemifumate) Tenofovir alafenamide fumarate, 2:1 L-Alanine,N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-,1-methylethyl ester,(2E)-2-butenedioate (2:1) Tenofovir Alafenamide fumate (E)-but-2-enedioic acid,propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate Tenofovir Alafenamide Fumate API 1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate Tenofovir Alafenamid Tenofovir Alafenamide fumate [USAN] Tenofovir Alafenamide fumateQ: What is Tenofovir Alafenamide fumate Q: What is the CAS Number of Tenofovir Alafenamide fumate GS-7340-03 Tenofovir alafenamide hemifumate GS7340(Tenofovir Alafenamide Fumate) 1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate,(2E)-2-butenedioate Tenofovir Alafenamide Hemifumate(2:1) CRS (S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumate Tenofovir levamide amine fumate Tenofovir alafenamide fumarate Celiprolol Impurity 8(Celiprolol Impurity H) (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumate(2:1) L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1) Isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumate 2-fluoro-5-[(4' -0x'H-phthalazin-1'-yl)methyllbenzoic acide' API-Anti-HBV Tenofovir alafenamide hemifumate, 10 mM in DMSO Phosphonoformic Acid Fumate N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1) Tenofovir dipivoxil phenol amine fumate N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester GS-7340 (hemifumarate) Tenofovir Alafenamide Hemifumate salt[USAN GS-7340 (hemifumate)\|\|\|Tenofovir alafenamide fumate Alafenamide hemifumate

Description	Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
Target	HIV-1, NRTIs[1]
In Vitro	Tenofovir alafenamide (GS-7340) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT[2].
In Vivo	Tenofovir alafenamide (GS-7340) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) [1].
References	[1]. Birkus G, et al. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors. Antimicrob Agents Chemother. 2015 Oct 26;60(1):316-22. [2]. Callebaut C, et al. In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate. Antimicrob Agents Chemother. 2015 Oct;59(10):5909-16.

Molecular Formula	C₄₆H₆₂N₁₂O₁₄P₂
Molecular Weight	1069.0
Exact Mass	1068.39836869
PSA	381.18000
LogP	7.60180
Storage condition	2-8°C

Hazard Codes	Xi

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1694615-29-6	1691683-72-3
1695151-45-1	1700493-43-1
1700235-81-9	1699555-07-1
1696006-07-1	1690969-60-8
1700148-24-8	1697708-27-2