98603-84-0

98603-84-0 structure

Name: Sialyl-Lewis X
Chemical Name: sialyl lewis x
CAS Number: 98603-84-0
Molecular Formula: C₃₁H₅₂N₂O₂₃
Molecular Weight: 820.74400
Catalog: Biochemical Carbohydrate Oligosaccharide
Create Date: 2018-08-20 18:23:50
Modify Date: 2024-01-03 21:32:47
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2].

Name	sialyl lewis x
Synonyms	SLEX,SODIUM SALT S LEX Sialyl Lex tri SSEA 1 3'-SIALYL-LEWIS-X TETRASACCHARIDE MFCD00270073 Lewis Sugars 3'-SIALYL-LEWISX 3'-SIALYL LEWIS

Description	Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Sialyl-Lewis X is a high-affinity ligand of CD62, Antibodies [mAb CSLEX (IgM; anti-sLeX)] to sLeX inhibit CD62-mediated binding of HL-60 cells to activated platelets[1]. Liposomes containing glycolipids with the sLeX structure prevents adhesion of HL-60 cells and human neutrophils. HL-60 cell adhesion is partially inhibited (50%) by liposomes containing Lex at 5 μg/ml. However, sLeX liposomes give maximal inhibition at only 1 ug/ml. sLeX liposomes inhibits adhesion with a 10-fold higher affinity than Lex liposomes[1]. CD62 binding of neutrophils to activated platelets is inhibited a soluble human milk oligosaccharide that contains the LeX structure. the sLeX sugar is a 30-fold more potent inhibitor than the nonsialylated Lex sugar, which requires 2 μg/ml and 54 μg/ml to achieve 50% inhibition of neutrophil adhesion, respectively[1].
References	[1]. M J Polley, et al. CD62 and Endothelial Cell-Leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, sialyl-Lewis X. Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6224-8. [2]. L A Lasky, et al. Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation. Science

Density	1.66g/cm3
Boiling Point	1285.8ºC at 760mmHg
Molecular Formula	C₃₁H₅₂N₂O₂₃
Molecular Weight	820.74400
Flash Point	731.4ºC
Exact Mass	820.29600
PSA	410.71000
Index of Refraction	1.653
Storage condition	−20°C
Stability	Store in freezer

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

98603-84-0	141612-87-5
92448-22-1	152932-65-5
91847-18-6	359436-57-0
25541-09-7	146697-03-2
71208-06-5	176106-81-3
1158522-08-7	940364-43-2
134104-43-1	1251689-76-5
921789-56-2	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	922036-92-8