Sialyl-Lewis X
Modify Date: 2024-01-03 21:32:47
Sialyl-Lewis X structure
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Common Name | Sialyl-Lewis X | ||
|---|---|---|---|---|
| CAS Number | 98603-84-0 | Molecular Weight | 820.74400 | |
| Density | 1.66g/cm3 | Boiling Point | 1285.8ºC at 760mmHg | |
| Molecular Formula | C31H52N2O23 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 731.4ºC | |
Use of Sialyl-Lewis XSialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2]. |
| Name | sialyl lewis x |
|---|---|
| Synonym | More Synonyms |
| Description | Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2]. |
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| Related Catalog | |
| In Vitro | Sialyl-Lewis X is a high-affinity ligand of CD62, Antibodies [mAb CSLEX (IgM; anti-sLeX)] to sLeX inhibit CD62-mediated binding of HL-60 cells to activated platelets[1]. Liposomes containing glycolipids with the sLeX structure prevents adhesion of HL-60 cells and human neutrophils. HL-60 cell adhesion is partially inhibited (50%) by liposomes containing Lex at 5 μg/ml. However, sLeX liposomes give maximal inhibition at only 1 ug/ml. sLeX liposomes inhibits adhesion with a 10-fold higher affinity than Lex liposomes[1]. CD62 binding of neutrophils to activated platelets is inhibited a soluble human milk oligosaccharide that contains the LeX structure. the sLeX sugar is a 30-fold more potent inhibitor than the nonsialylated Lex sugar, which requires 2 μg/ml and 54 μg/ml to achieve 50% inhibition of neutrophil adhesion, respectively[1]. |
| References |
| Density | 1.66g/cm3 |
|---|---|
| Boiling Point | 1285.8ºC at 760mmHg |
| Molecular Formula | C31H52N2O23 |
| Molecular Weight | 820.74400 |
| Flash Point | 731.4ºC |
| Exact Mass | 820.29600 |
| PSA | 410.71000 |
| Index of Refraction | 1.653 |
| Storage condition | −20°C |
| Stability | Store in freezer |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Feizi, T.
Curr. Opin. Struct. Biol. 3 , 701, (1993)
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| SLEX,SODIUM SALT |
| S LEX |
| Sialyl Lex tri |
| SSEA 1 |
| 3'-SIALYL-LEWIS-X TETRASACCHARIDE |
| MFCD00270073 |
| Lewis Sugars |
| 3'-SIALYL-LEWISX |
| 3'-SIALYL LEWIS |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Sialyl-Lewis X
- Price: ￥3668.0/1mg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Sialyl-Lewis X
- Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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