392711-19-2

392711-19-2 structure

Name: Rapamycin-d3
Chemical Name: Rapamycin-d3
CAS Number: 392711-19-2
Molecular Formula: C₅₁H₇₆D₃NO₁₃
Molecular Weight: 917.19000
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2016-06-22 18:04:07
Modify Date: 2025-09-01 16:13:29
Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Name	Rapamycin-d3
Synonyms	[2H3]-Sirolimus Rapamycin,7-O-demethyl-7-O-(methyl-d3)

Description	Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401. [2]. Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30(34):11388-97.

Hazard Codes	Xi