Rapamycin-d3

Modify Date: 2024-01-16 15:59:09

Rapamycin-d3 structure	Common Name	Rapamycin-d3
	CAS Number	392711-19-2	Molecular Weight	917.19000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₁H₇₆D₃NO₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Rapamycin-d3

Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

Name	Rapamycin-d3
Synonym	More Synonyms

Description	Rapamycin-d3 (Sirolimus-d3) is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
References	[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401. [2]. Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30(34):11388-97.

Description

Related Catalog

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

References

[1]. Edwards SR, et al. The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem, 2007, 282(18), 13395-13401.

[2]. Rangaraju S, et al. Rapamycin activates autophagy and improves myelination in explant cultures from neuropathicmice. J Neurosci. 2010 Aug 25;30(34):11388-97.

Molecular Formula	C₅₁H₇₆D₃NO₁₃
Molecular Weight	917.19000
Exact Mass	916.57400
PSA	195.43000
LogP	6.11850

Hazard Codes	Xi

[2H3]-Sirolimus

Rapamycin,7-O-demethyl-7-O-(methyl-d3)

Rapamycin-d3

Use of Rapamycin-d3

Names

Rapamycin-d3 Biological Activity

Chemical & Physical Properties

Safety Information

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