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69-81-8

69-81-8 structure
69-81-8 structure
  • Name: Carbazochrome
  • Chemical Name: Carbazochrome
  • CAS Number: 69-81-8
  • Molecular Formula: C10H12N4O3
  • Molecular Weight: 236.227
  • Catalog: API Blood system medication Hemostatic drug
  • Create Date: 2018-07-02 16:59:38
  • Modify Date: 2026-07-09 18:26:36
  • Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].
Name Carbazochrome
Synonyms ctabes
adchnon
Adrenochrome semicbazone
ADRENOCHROME SEMICBAZIDE
ADRENOCHROME MONOSEMICBAZONE
Export of blood
2-[(1,2,3,6-Tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indole)-5-ylidene]hydrazinecbimide amide
Cbazochrome-8
EINECS 200-717-0
3-Hydroxy-1-methyl-5,6-indolindione 5-semicbazone
Cbazochrome, 10 mM in DMSO
2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxoindol-5-ylidene)-hydrazinecboxamide
Adrenochrom-monosemicarbazon
Cbazochrome >
Cbazochrome Cbazochrome
cbazochrom
ADENOCHROME SEMICBAZONE
ADRENOXYL
adrenostazin
CROMADRENAL
adedolon
sangostasin
3-hydroxy-1-methyldihydroindole-5,6-dione cbamide
An network of blood (adrenal color hydrazone)
(2Z)-2-(3-Hydroxy-1-methyl-6-oxo-1,2,3,6-tetrahydro-5H-indol-5-ylidene)hydrazinecarboxamide
MFCD00130253
3-HYDROXY-1-METHYL-5,6-INDOLINEDION 5-SEMICBAZONE
6-indolinedione,3-hydroxy-1-methyl-5-semicbazone
5,6-Indolinedione, 3-hydroxy-1-methyl-, 5-semicbazone (7CI, 8CI)
adenocromemonosemicbazone
1,2,3,5-Tetrahydro-5-(2-amidinohydrazono)-3-hydroxy-1-methyl-6H-indole-6-one
cartabes
2-(3-Hydroxy-1-Methyl-6-oxo-2,3-dihydro-1H-indol-5(6H)-ylidene)hydrazinecboxaMide
CROMOSIL
Hydrazinecboxamide, 2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)
C10045850 AdrenochromEsemicbazone
adrezon
Cbazochrome DMF, FORM41
Kabaklo
hydrazinecboxamide,2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5h-indol
CbazochromeQ: What is Cbazochrome Q: What is the CAS Number of Cbazochrome Q: What is the storage condition of Cbazochrome
Cbazochrome
Cbazochrome Sodium Sulfonate Impurity A
Adrenobazon
3-HYDROXY-1-METHYL-5,6-INDOLINEDIONE SEMICBAZONE
Adrenochrome Semicbazone Powder Cbazochrome
Adrenochrome semicbazone (6CI)
adroxon
Cbazochrome (DMF)
Cbazochrome //BP
sangostazin
Monosemicbazone
3-hydroxy-1-methyl-5,6-indolinedione 5-semicbazone
Adrenochrome Semicbazone Cbazochrome
5-ylidene)
[(2-hydroxy-1-methyl-6-oxo-2,3-dihydroindol-5-ylidene)amino]urea
adrokson
Description Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].
Related Catalog
In Vitro Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1].Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1].
In Vivo Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2]. Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2] Dosage: 10 mg/kg Administration: I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.). Result: Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.
References

[1]. Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80.

[2]. Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8.
Density 1.6±0.1 g/cm3
Melting Point 203° (dec)
Molecular Formula C10H12N4O3
Molecular Weight 236.227
Exact Mass 236.090942
PSA 108.02000
LogP -1.53
Index of Refraction 1.733
Storage condition −20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM1925500
CHEMICAL NAME :
5,6-Indolinedione, 3-hydroxy-1-methyl-, 5-semicarbazone
CAS REGISTRY NUMBER :
69-81-8
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C10-H12-N4-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>17280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2808572
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1276 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,1821,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>12500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,1821,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>35832 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2808572
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2413 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,1821,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,1821,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8349 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 197 (estimated) No. of Female Employees: 59 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS NM1925500
HS Code 2933990090
563-41-7 structure

563-41-7

~%

69-81-8 structure

69-81-8

Literature: Zhurnal Obshchei Khimii, , vol. 28, p. 3338,3341,3344;engl.Ausg.S.3364,3367
Precursor  1

DownStream  0

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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