Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Semicarbazide hydrochloride
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Purity: 98.0%
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563-41-7

563-41-7 structure

Name: Semicarbazide hydrochloride
Chemical Name: Semicarbazide hydrochloride
CAS Number: 563-41-7
Molecular Formula: CH₆ClN₃O
Molecular Weight: 111.531
Catalog: Chemical reagent Organic reagent Urea
Create Date: 2018-02-05 08:00:00
Modify Date: 2026-07-19 16:42:54
Semicarbazide hydrochloride, a derivative of urea, possesses antiviral, antiinfective and antineoplastic through binding to copper or iron in cells[1].

Name	Semicarbazide hydrochloride
Synonyms	SEM·HCl Semicbazide-13C,15N3 Semicbazide hydrochloride solution,100ppm Semicbaside SemicbazideHydrochlorideA.R ammourea hydrochloride 15N2, ) SeMicbazide hydrochloride p.a., >= (AT) SEMICARBAZIDE HCL SEMICBAZIDE HYDROCHLORIDE MFCD00013009 Trazodone Impurity 11 HCl Hydrazinecarboxamide hydrochloride Semicarbazide-13CHCl SEM·HCl Solution, 100ppm SEMICBAZIDE HYDROCHLORIDE FOR SYNTHESI Trazodone Impurity 5 EINECS 209-247-0 SEMICBAZIDE HYDROCHLORIDE R. G Semicrbazide Hydrochloride HydrazinecboxaMide,hydrochloride (1:1) semicarbazide-hydrochloride HYDRAZINE CBOXAMIDE HYDROCHLORIDE Semicbazide Hydrochloride Standd SemicbazideHydrochloride> Semicbazide hydrochloride test solution semicbazide,monohydrochloride Semikbazide hydrochloride Semicarbazide hydroc HYDRAZINE CBOXAMIDE MONOHYDROCHLORIDE SEMICBAZIDE HYDROCHLORIDE EXTRAPURE SEM CARBAMYLHYDRAZINEHCL Semicarbaside semicbazidechloride SEMICBAZIDE HYDROCHLORIDE, FOR ANALY-T ICAL PURPOSES SEMICBAZIDE HCL Semicbazide hydrochloride-13C15N3 SEMICBAZIDE CHLORHYDRATE CBAMYLHYDRAZINE HYDROCHLORIDE Semicbazidhydrochlorid Semicbazide-13C SCA-HCl CBAMIC ACID HYDRAZIDE HYDROCHLORIDE N-Aminourea hydrochloride, Hydrazine cboxamide hydrochloride semicarbazid SEMICBAZIDE HYDROCHLORIDE FOR ANALY Semicbazide hydrochloride Solution in Methanol Semicbazide hydrochloride test solution(ChP) Semicbazide hydrochloride reference substance Semicalbazide Chlorhydrate N-AMINOUREA HYDROCHLORIDE amidoureahydrochloride Semicbazide hydroc SIMICBAZIDECHLORHYDRATE Semicbazide-13CHCl CBAMYLHYDRAZINEHCL Semicbazide hydrochloride, synthesis ade AMINOUREA HYDROCHLORIDE SemicbazideHydrochlorideForSyanthesis SemicbazideHydrochloride Urea hydrochloride test solution semicarbazidechloride

Description	Semicarbazide hydrochloride, a derivative of urea, possesses antiviral, antiinfective and antineoplastic through binding to copper or iron in cells[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Adam Becalski, et al. Semicarbazide Formation in Azodicarbonamide-Treated Flour: A Model Study. J Agric Food Chem. 2004 Sep 8;52(18):5730-4.

Density	1.286g/cm3
Boiling Point	235.3ºC at 760 mmHg
Melting Point	175-177 °C (dec.)(lit.)
Molecular Formula	CH₆ClN₃O
Molecular Weight	111.531
Flash Point	66.5ºC
Exact Mass	111.019943
PSA	81.14000
LogP	1.12190
Vapour Pressure	0.0407mmHg at 25°C
Storage condition	-20°C Freezer, Under Inert Atmosphere
Stability	Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	100 g/L (15 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT3500000

CHEMICAL NAME :: Semicarbazide, monohydrochloride

CAS REGISTRY NUMBER :: 563-41-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C-H5-N3-O.Cl-H

MOLECULAR WEIGHT :: 111.55

WISWESSER LINE NOTATION :: ZVMZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 167 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg/30D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2400 mg/kg/30D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67 gm/kg/76W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 74 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 550 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Insect - grasshopper

DOSE/DURATION :: 100 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,237,1976 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,209,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 12,209,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7190 No. of Facilities: 41 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2815 (estimated) No. of Female Employees: 1055 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/38;R40
Safety Phrases	S24/25-S22-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	VT3500000
Packaging Group	III
Hazard Class	6.1
HS Code	2928000090

Precursor 10
590-28-3 10034-93-2 745076-15-7 745076-14-6
745076-16-8 28787-22-6 1574-10-3 38132-39-7
7647-01-0 39130-96-6
DownStream 10
106324-36-1 105224-04-2 106659-98-7 33050-32-7
59-87-0 14923-66-1 14534-93-1 14066-73-0
4512-00-9 434-13-9

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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