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426-13-1

426-13-1 structure
426-13-1 structure
  • Name: fluoromethalone
  • Chemical Name: fluorometholone
  • CAS Number: 426-13-1
  • Molecular Formula: C22H29FO4
  • Molecular Weight: 376.462
  • Catalog: API Hormone and endocrine-regulating drugs Adrenal corticosteroids
  • Create Date: 2018-07-17 09:11:50
  • Modify Date: 2026-07-07 17:30:39
  • Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used in the management of dry eye[1].
Name fluorometholone
Synonyms EINECS 207-041-5
FLUOROMETHOLONE
pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-,(6alpha,11be
Flulon
(6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
delmeson
Fluaton PVA
11BETA,17ALPHA-DIHYDROXY-9-FLUORO-6-METHYL-1,4-PREGNADIENE-3,20-DIONE
6α-Methyl-9α-fluoro-21-desoxyprednisolone
Loticort
Fluor-Op
MFCD00056461
21-Desoxy-9a-fluoro-6-methylprednisolone
Fluorometholone,11β,17α-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
FML SOP
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6α,11β)
luoroMethalone
Fluorometholone solution,100ppm
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-6α-methyl- (6CI, 7CI, 8CI)
9-alpha-fluoro-11-beta,17-alpha-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
FLAREX
FML Forte
21-DESOXY-9A-FLUORO-6-ALPHA-METHYLPREDNISOLONE
9a-Fluoro-11b,17a-dihydroxy-6a-methylpregna-1,4-diene-3,20-dione
11-BETA,17-ALPHA-DIHYDROXY-9-FLUORO-6-METHYL-4-ANDROSTEN-3-ONE
9-fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11,17-Dihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione
FLUOROMETHOLONE,POWDER
21-Desoxy-9a-fluoro-6a-methylprednisolone
6α-Methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione
Fluorometholone>
Fluoron
Flumetholon
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
(6α,11β)-9-Fluoro-11,17-dihydroxy-6-Methylpregna-1,4-diene-3,20-dione
Ursnon
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acétyl-9-fluoro-11,17-dihydroxy-6,10,13-triméthyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one
20-dione,9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl-pregna-4-diene-3
cortilet
Fluoromethalone
21-Desoxy-6a-methyl-9a-fluoroprednisolone
Fluormetholon
21-Desoxy-9α-fluoro-6-methylprednisolone
uorometholone
Fluorometholone -1
Fluoro methalone
11b,17a-dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
4-amino-1-methyl-3-pyrazolo[3,4-d]pyrimidinecbonitrile
FML Liquifilm
trilcin
6a-Methyl-9a-fluoro-21-desoxyprednisolone
nsc33001
(6a,11b)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
1,4-PREGNADIEN-9-ALPHA-FLUORO-6-ALPHA-METHYL-11-BETA, 17-DIOL-3,20-DIONE
(6S,8S,9R,10S,11S,13S,14S,17R)-17-ethanoyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
oxylone
9a-fluoro-11b,17a-dihydroxy-6a-methyl-1,4-pregnadiene-3,20-dione
Fluorometholone RS
Efflumidex
9-FLUORO-11,17-DIHYDROXY-6-METHYLPREGNA-1,4-DIENE-3,20-DIONE
pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-,(6-alpha,11-be
11β,17α-dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
Fluorometholone Fluorometholone
(6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluor-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-Methyl-, (6a,11b)
Fluaton
Description Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used in the management of dry eye[1].
Related Catalog
Target

glucocorticoid receptor[1]

In Vitro Fluorometholone (25-100 nM; 12 hours, 24 hours) increases the gene expression of MUC1, MUC4, MUC16 and MUC19 in the conjunctival and corneal epithelial cells through activation of glucocorticoid receptors[1].
References

[1]. Jonathan Taniguchi, et al. Fluorometholone Modulates Gene Expression of Ocular Surface Mucins. Acta Ophthalmol. 2019 Dec;97(8):e1082-e1088.
Density 1.3±0.1 g/cm3
Boiling Point 527.1±50.0 °C at 760 mmHg
Melting Point 292 - 303ºC
Molecular Formula C22H29FO4
Molecular Weight 376.462
Flash Point 272.6±30.1 °C
Exact Mass 376.204987
PSA 74.60000
LogP 2.02
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.574

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3834100
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-
CAS REGISTRY NUMBER :
426-13-1
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C22-H29-F-O4
MOLECULAR WEIGHT :
376.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
443 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,981,1990
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2800 ug/kg/28D-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3684 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TU3834100
HS Code 2937229000
Precursor  2

DownStream  0

HS Code 2937229000
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