77275-70-8

77275-70-8 structure

Name: [D-Pro2,D-Phe7,D-Trp9]-Substance P
Chemical Name: [D-Pro2,D-Phe7,D-Trp9]-Substance P
CAS Number: 77275-70-8
Molecular Formula: C₇₂H₁₀₅N₁₉O₁₃S
Molecular Weight: 1476.79000
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-28 11:48:44
Modify Date: 2024-01-05 16:39:22
[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].

Name	[D-Pro2,D-Phe7,D-Trp9]-Substance P
Synonyms	substance P,Pro(2)-Phe(7)-Trp(9) Substance P,(D-Pro2,D-Phe7,D-Trp9) ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2 (D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P) (D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2

Description	[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Substance P[2]
In Vitro	[D-Pro2,D-Phe7,D-Trp9] Substance P (10-100 μM; 2 min or 10 min) produces dose-related contractions of the guinea-pig ileum and in the rabbit external jugular vein[1].
In Vivo	[D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2].
References	[1]. Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8. [2]. Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6.