[D-Pro2,D-Phe7,D-Trp9]-Substance P

Modify Date: 2025-09-17 08:50:44

[D-Pro2,D-Phe7,D-Trp9]-Substance P structure	Common Name	[D-Pro2,D-Phe7,D-Trp9]-Substance P
	CAS Number	77275-70-8	Molecular Weight	1476.79000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇₂H₁₀₅N₁₉O₁₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [D-Pro2,D-Phe7,D-Trp9]-Substance P

[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].

Name	[D-Pro2,D-Phe7,D-Trp9]-Substance P
Synonym	More Synonyms

Description	[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Substance P[2]
In Vitro	[D-Pro2,D-Phe7,D-Trp9] Substance P (10-100 μM; 2 min or 10 min) produces dose-related contractions of the guinea-pig ileum and in the rabbit external jugular vein[1].
In Vivo	[D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2].
References	[1]. Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8. [2]. Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6.

Molecular Formula	C₇₂H₁₀₅N₁₉O₁₃S
Molecular Weight	1476.79000
Exact Mass	1475.79000
PSA	557.72000
LogP	6.28670

substance P,Pro(2)-Phe(7)-Trp(9)

Substance P,(D-Pro2,D-Phe7,D-Trp9)

ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2

(D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P)

(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P

H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2

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[D-Pro2,D-Phe7,D-Trp9]-Substance P

Use of [D-Pro2,D-Phe7,D-Trp9]-Substance P

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[D-Pro2,D-Phe7,D-Trp9]-Substance P Biological Activity

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