Name | (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide |
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Synonyms |
Tyr-pro-trp-gly-NH2
[Tyr0,Trp2]-MIF-I Tyr-W-mif-1 Tyr-[Trp2]-Melanocyte Stimulating Hormone Release Inhibiting Factor trifluoroacetate salt L-Tyrosyl-L-prolyl-L-tryptophylglycinamide Tyrosyl-prolyl-tryptophyl-glycinamide Tyr-W-MIF-I Glycinamide,L-tyrosyl-L-prolyl-L-tryptophyl |
Description | Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5]. |
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Related Catalog | |
In Vitro | Tyr-W-MIF-1 (1-10 μM) 抑制 LC 神经元的自发放电[1]。 Tyr-W-MIF-1 减弱 Morphine (3 μM) 诱导的 SH-SY5Y 人神经母细胞瘤细胞中 mu 和 delta 受体的下调[4]。 Tyr-W-MIF-1 (0.3 μM) 抑制3H-DAMGO (对μ阿片受体有选择性) 与大鼠脑的结合[5]。 |
In Vivo | Tyr-W-MIF-1 (i.c.v,5 μL, 200 μg) 诱导大鼠镇痛时间延长[2]。 Tyr-W-MIF-1 (i.t., 0.75 μg) 诱导镇痛,并被 Naloxone 逆转[3]。 Animal Model: Rats[2] Dosage: 200 μg in 5 μL Administration: Intracerebroventricular injection (i.c.v) Result: Prolonged analgesia, measured by latency to remove the tail from a heating element. |
References |
Density | 1.38 g/cm3 |
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Boiling Point | 1009.2ºC at 760 mmHg |
Molecular Formula | C29H33F3N6O7 |
Molecular Weight | 634.60400 |
Flash Point | 564.2ºC |
Exact Mass | 634.23600 |
PSA | 220.94000 |
LogP | 2.81690 |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.67 |