(Tyr0,Trp2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor

Modify Date: 2025-08-26 09:19:29

(Tyr0,Trp2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor structure	Common Name	(Tyr0,Trp2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor
	CAS Number	144450-13-5	Molecular Weight	634.60400
	Density	1.38 g/cm3	Boiling Point	1009.2ºC at 760 mmHg
	Molecular Formula	C₂₉H₃₃F₃N₆O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	564.2ºC

Use of (Tyr0,Trp2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor

Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5].

Name	(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
Synonym	More Synonyms

Description	Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia[1][2][5].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	Tyr-W-MIF-1 (1-10 μM) 抑制 LC 神经元的自发放电[1]。 Tyr-W-MIF-1 减弱 Morphine (3 μM) 诱导的 SH-SY5Y 人神经母细胞瘤细胞中 mu 和 delta 受体的下调[4]。 Tyr-W-MIF-1 (0.3 μM) 抑制3H-DAMGO (对μ阿片受体有选择性) 与大鼠脑的结合[5]。
In Vivo	Tyr-W-MIF-1 (i.c.v，5 μL, 200 μg) 诱导大鼠镇痛时间延长[2]。 Tyr-W-MIF-1 (i.t., 0.75 μg) 诱导镇痛，并被 Naloxone 逆转[3]。 Animal Model: Rats[2] Dosage: 200 μg in 5 μL Administration: Intracerebroventricular injection (i.c.v) Result: Prolonged analgesia, measured by latency to remove the tail from a heating element.
References	[1]. Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40(3):131-5. [2]. Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides. 1994;15(8):1505-11. [3]. Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298(3):235-9. [4]. Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284(2):611-7. [5]. Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides. 1992 Jul-Aug;13(4):623-31.

Density	1.38 g/cm3
Boiling Point	1009.2ºC at 760 mmHg
Molecular Formula	C₂₉H₃₃F₃N₆O₇
Molecular Weight	634.60400
Flash Point	564.2ºC
Exact Mass	634.23600
PSA	220.94000
LogP	2.81690
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.67

MSDS(Chinese)

Tyr-pro-trp-gly-NH2

[Tyr0,Trp2]-MIF-I

Tyr-W-mif-1

Tyr-[Trp2]-Melanocyte Stimulating Hormone Release Inhibiting Factor trifluoroacetate salt

L-Tyrosyl-L-prolyl-L-tryptophylglycinamide

Tyrosyl-prolyl-tryptophyl-glycinamide

Tyr-W-MIF-I

Glycinamide,L-tyrosyl-L-prolyl-L-tryptophyl

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