84057-95-4
84057-95-4 structure
- Name: Ropivacaine
- Chemical Name: (S)-ropivacaine
- CAS Number: 84057-95-4
- Molecular Formula: C17H26N2O
- Molecular Weight: 274.401
- Catalog: API Anesthetic Agents Local anesthetics
- Create Date: 2018-08-03 19:08:19
- Modify Date: 2026-07-04 01:24:05
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Ropivacain is a potent sodium channel blocker and acts as a local anesthetic agent. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of regional anesthesia and neuropathic pain management[1].
| Name | (S)-ropivacaine |
|---|---|
| Synonyms |
(S)-ROPIVACAINE HCL
(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide (S)ROPIVACAINE HYDROCHLORIDE (S)-ROPIVACAINEHYDROCHLORIDE (-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide (S)ROPIVACAINE HY DROCHLORIDE 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-, hydrochloride, hydrate (1:1:1) S-ROPIVACAINE HCL (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Ropivacaine API (S)-(-)-1-propyl-2',6'-pipecoloxylidide ROPACAINEHCL ROPACARAINEHCL MFCD00864425 RopivacaineHcl/MesylateBase (S)-N-(2，6-Dimethylphenyl)-1-pKIpyl-2-piperidinecboxamide ROM. Pp because Ropivacaine hydrochloride (S)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride monohydrate (-)-1-Propyl-2',6'-pipecoloxylidide Ropivacaine, 10 mM in DMSO (S)-ropivacaine hydrochloride hydrate Ropivacaine //BP Ropivacaine Free base ROPIVACAINE Ropivacaine HCl.H2O Ziresovir Impurity 3 Ropivacaine HCl Nopine (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate Ropivacaine HCl (base) (S)-ROPIVACAINE HYDROCHLORIDE UNII-V910P86109 (S)-(-)-ropivacaine n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-cboxamide (2S)-N-(2,6-dimethylphenyl)-1-propyl-piperidine-2-cboxamide Ropivacaine hydrochloride Monohydrate Ropivacaine (hydrochloride Monohydrate) (+-)-ropivacaine hydrochloride (S)-ROPIVACAINEHCL Ropivacaine Base With S-ROPIVACAINEHCL Ropivacaine HCl 84-4 Seduron 2-Piperidinecboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S) RopivacaineQ: What is Ropivacaine Q: What is the CAS Number of Ropivacaine Q: What is the storage condition of Ropivacaine Q: What e the applications of Ropivacaine (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecboxamide Ropivacainehydrochloride Naropin (2r,2'r,3r,3'r,4r)-2,2'-bis(3,4-dihydroxyphenyl)-5,5',7,7'-tetrahydroxy-3,3',4,4'-tetrahydro-2h,2',8'-bichromene-3,3'-diyl bis(3,4,5-trihydroxybenzoate) l-N-n-Propylpipecolic acid-2,6-xylidide ROPIVACAINE MESYLATER UNII-7IO5LYA57N Nopin (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-cboxamide S-ROPIVACAINE MesylateBase (S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide Naropine (S)-N-propylpiperidine-2-carboxylic acid 2,6-dimethylphenyl amide ROPIVACAINE CAS NO:84-4 ropivacaine hydrochloride hydrate (2S)-1-Propyl-2-(2,6-dimethylphenyl)cbamoylpiperidine Ropivacainebase S-ROPIVACAINE HYDROCHLORIDE (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride hydrate (2S)-1-Propyl-N-(2,6-dimethylphenyl)piperidine-2-cboxamide |
| Description | Ropivacain is a potent sodium channel blocker and acts as a local anesthetic agent. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of regional anesthesia and neuropathic pain management[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: sodium ion influx[1] IC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)[2] |
| In Vivo | Epidural administration of Ropivacaine effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1]. Ropivacaine inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2]. Ropivacaine prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2]. Ropivacaine inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2]. Animal Model: Adult Sprague-Dawley rats (300–400g)[1] Dosage: 1 μM Administration: Infusion (added to the perfusate reservoir) Result: Attenuated pressure-dependent increases in filtration coefficient (Kf). |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 410.2±45.0 °C at 760 mmHg |
| Melting Point | 144 - 146ºC |
| Molecular Formula | C17H26N2O |
| Molecular Weight | 274.401 |
| Flash Point | 201.9±28.7 °C |
| Exact Mass | 274.204498 |
| PSA | 32.34000 |
| LogP | 3.11 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Storage condition | -20℃ |
| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | 36/37/39-26 |
| WGK Germany | 3 |
| RTECS | LK8650000 |
| HS Code | 2933399090 |
|
~90%
84057-95-4 |
| Literature: BRIDGE PHARMA, INC. Patent: WO2008/88756 A1, 2008 ; Location in patent: Page/Page column 34 ; |
|
~93%
84057-95-4 |
| Literature: L. MOLTENI and C. DEI FRATELLI ALITTI - SOCIETA DI ESERCIZIO S.P.A. Patent: WO2006/133837 A2, 2006 ; Location in patent: Page/Page column 3-4 ; |
| Precursor 3 | |
|---|---|
| DownStream 2 | |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |