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34368-04-2

34368-04-2 structure

Name: dobutamine
Chemical Name: dobutamine
CAS Number: 34368-04-2
Molecular Formula: C₁₈H₂₃NO₃
Molecular Weight: 301.38000
Catalog: API Circulatory system medication Anti-shock vasoactive drug
Create Date: 2018-04-02 08:00:00
Modify Date: 2024-01-03 10:18:28
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4].

Name	dobutamine
Synonyms	4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol DOBUTAMINE HCL 1,2-Benzenediol,4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-,(+-) (+/-)-dobutamine DOBUTAMINE HYDROCHLORIDE 4-[2-[4-(4-HYDROXYPHENYL)BUTAN-2-YLAMINO]ETHYL]BENZENE-1,2-DIOL

Description	Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vivo	Dobutamine has a rapid onset of action and a short half-life [2]. Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3]. Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3]. Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq44 mice[3]. Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3]. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4]. Animal Model: Tgαq44 mice (heart failure models)[3] Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose Administration: Intraperitoneal injection Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure.
References	[1]. Tuttle RR, et al. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975 Jan;36(1):185-96. [2]. Vallet B, et al. Dobutamine: mechanisms of action and use in acute cardiovascular pathology. Ann Cardiol Angeiol (Paris). 1991 Jun;40(6):397-402. [3]. Tyrankiewicz U , et al. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013 Mar;37(3):669-77. [4]. Tibayan FA, et al. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):438-44.

Density	1.189g/cm3
Boiling Point	527.7ºC at 760mmHg
Molecular Formula	C₁₈H₂₃NO₃
Molecular Weight	301.38000
Flash Point	169.8ºC
Exact Mass	301.16800
PSA	72.72000
LogP	3.34770
Storage condition	2-8°C

Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22-63
Safety Phrases	22-26-36/37/39
WGK Germany	3
HS Code	2922509090

61413-44-3

~92%

34368-04-2

Literature: SUN PHARMACEUTICAL INDUSTRIES LIMITED Patent: WO2008/47382 A2, 2008 ; Location in patent: Page/Page column 22 ;

120-20-7

3815-30-3

34368-04-2

61413-44-3

Literature: US3987200 A1, ;

1020073-90-8

34368-04-2

Literature: WO2008/47382 A2, ; Page/Page column 21 ;

Precursor 3
61413-44-3 120-20-7 3815-30-3
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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