26644-46-2

26644-46-2 structure

Name: Triforine
Chemical Name: triforine
CAS Number: 26644-46-2
Molecular Formula: C₁₀H₁₄Cl₆N₄O₂
Molecular Weight: 434.96
Catalog: Chemical pesticide Fungicide Other fungicides
Create Date: 2018-07-14 17:48:23
Modify Date: 2026-06-30 18:09:31
Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi[1].

Name	triforine
Synonyms	Triforine in Acetonitrile N,N'-(1,4-piperazinediyl bis (2,2,2-trichloro) ethylidene) bis formamide cela50 Triforine Solution, 1000ppm FUNDINEX(R) N,N'-[1,4-Piperazinediylbis(2,2,2-trichloro-1,1-ethanediyl)]diformamide Caswell No. 890AA DENIN(R) n,n’-(piperazinediylbis(2,2,2-trichloroethylidene))bis(formamide) 1,4-bis(1-formamido-2,2,2-trichloroethyl)-piperazin N,N'-[Piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]diformamide Triforine @100 μg/mL in MeOH Triforine Standd (mixture of isomers) N,N'-[Piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]bisformamide n,n’-(1,4-piperazinediylbis(2,2,2-trichloroethylidene))bis-formamid Biformylchlorazin N,N’-[piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]diformamide 1,4-Bis(2,2,2-trichoro-1-formamidoethyl)piperazine N,N'-(piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl))diformamide N,N’-[1,4-Piperazinediylbis(2,2,2-trichloro-ethylidene)]-bisformamide CW 524 EINECS 247-872-0 1,4-bis-(2,2,2-trichloro-1-formamidoethyl)-piperazine Asta Funginex triforine (bsi,iso,ansi,jmaf) N-[2,2,2-trichloro-1-[4-(2,2,2-trichloro-1-formamidoethyl)piperazin-1-yl]ethyl]formamide ca70203 MFCD00055521 Benzoylprop-ethyl Impurity 15 N,N'-[Piperazin-1,4-diylbis(2,2,2-trichlorethan-1,1-diyl)]diformamid Triforine 0.25 biformylchlorazin 1,4-bis(1-formamido-2,2,2-trichloroethyl)piperazine TRIFORIN PESTANAL Denin TRIFORINE, 100M, NEAT N,N’-[1,4-piperazinediylbis(2,2,2-trichloroethylidene)]bis[formamide] FUNGINEX CELA 50 SAPROL(R) TRIFORIN Formamide, N,N-1,4-piperazinediylbis(2,2,2-trichloroethylidene)bis N,N'-[PIPERAZINE-1,4-DIYLBIS(TRICHLOROMETHYL)METHYLENE]-DIFORMAMIDE Denin(Cela Merck) w524 1，4-di(2,2,2-trichloro-1-formamidoethyl) piperazine Triforine (mixture of isomers) Funginex Triforine 100mg [26-2] Saprol CELA W524 Triforin PIPERAZIN-1,4-DIYL-BIS-[1-(2,2,2-TRICHLOROETHYL)FORMAMIDE] cw524 1,4-BIS(2,2,2-TRICHLORO-1-FORMAMIDOETHYL)-PIPERAZINE TRIFORINE cme74770 Triforine 100 μg/ml Acetonitrile N,N’-{piperazine-1,4-diylbis[(trichloromethyl)methylene]}diformamide SAPROL n,n’-bis(1-formamido-2,2,2-trichloroethyl)piperazine Triforine 10 μg/ml Acetonitrile riforine N,N'-(2,2,2,2',2',2'-hexachloro-1,1'-piperazine-1,4-diyl-diethyl)-bis-formamide biformychlorazin

Description	Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
References	[1]. Fuchs, A, et al. Laboratory and greenhouse evaluation of a new systemic fungicide, NN'-bis-(1-formamido-2,2,2,-trichloroethyl)-piperazine (CELA W 524) [1971]. Netherlands journal of plant pathology. ISSN : 0028-2944.

Density	1.6±0.1 g/cm3
Boiling Point	561.5±50.0 °C at 760 mmHg
Melting Point	155ºC (decomposes)
Molecular Formula	C₁₀H₁₄Cl₆N₄O₂
Molecular Weight	434.96
Flash Point	293.4±30.1 °C
Exact Mass	431.924805
PSA	64.68000
LogP	4.61
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.571

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK9200000

CHEMICAL NAME :: Piperazine, 1,4-bis(1-formamido-2,2,2-trichloroethyl)-

CAS REGISTRY NUMBER :: 26644-46-2

BEILSTEIN REFERENCE NO. :: 0626358

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H14-Cl6-N4-O2

MOLECULAR WEIGHT :: 434.98

WISWESSER LINE NOTATION :: T6N DNTJ AYMVHXGGG DYMVHXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 180 uL/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Taste) - change in function

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 4,554,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 4,81,1976/1977

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4500 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A413,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A413,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A413,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991 *** REVIEWS *** TOXICOLOGY REVIEW 27ZTAP "Clinical Toxicology of Commercial Products--Acute Poisoning," 3rd ed., Gleason, M.N., et al., eds., Baltimore, Williams and Wilkins, 1969 Volume(issue)/page/year: 3,126,1969 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2601 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 644 (estimated) No. of Female Employees: 123 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H332
Hazard Codes	Xn
Risk Phrases	52/53-20
Safety Phrases	61
RIDADR	UN3077 (solid); UN3082 (liquid)
RTECS	TK9200000
HS Code	2933599019

HS Code	2933599019
Summary	2933599019 n,n'-(piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl))diformamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

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