5230-87-5

5230-87-5 structure

Name: Anisatin
Chemical Name: anisatin
CAS Number: 5230-87-5
Molecular Formula: C₁₅H₂₀O₈
Molecular Weight: 328.31500
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-04-04 08:00:00
Modify Date: 2024-01-06 17:30:59
Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].

Name	anisatin
Synonyms	Fruit of illicium anisatum L.

Description	Anisatin, a pure toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum) acts as a picrotoxin-like, non-competitive GABA antagonist. Anisatin suppresses GABA-induced currents in a concentration-dependent manner with an EC50 of ~1.10 μM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Anisatin inhibits [3H]diazepam binding enhanced by either GABA or pentobarbital, without affecting the basal specific binding to rat brain membranes[1].
In Vivo	In mice, the LD50 reported for anisatin ranges from 0.76 to 1 mg/kg (po and ip)[1].
References	[1]. Ikeda T, et al. Anisatin modulation of the gamma-aminobutyric acid receptor-channel in rat dorsal root ganglion neurons. Br J Pharmacol. 1999;127(7):1567-1576. [2]. Bao X, et al. Bioavailability and Pharmacokinetics of Anisatin in Mouse Blood by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry. Biomed Res Int. 2020;2020:8835447. Published 2020 Dec 23.

CHEMICAL NAME :: Spiro(6H-4,9a-methanocyclopent(d)oxocin-6,3'-oxetane) -2,2'(1H)-dione, 4a-beta,5,6a,7,8,9- hexahydro-5,9a-dimethyl-1-alpha,5-beta,6a-beta,7-beta -tetrahydroxy-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 44,1908,1996

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Skin and Appendages - hair

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,524,1959