329-63-5

329-63-5 structure

Name: Epinephrine Hydrochloride
Chemical Name: dl-adrenaline hydrochloride
CAS Number: 329-63-5
Molecular Formula: C₉H₁₄ClNO₃
Molecular Weight: 219.665
Create Date: 2018-02-08 08:00:00
Modify Date: 2024-01-02 18:10:58

Name	dl-adrenaline hydrochloride
Synonyms	[3H]-(+/-)-Epinephrine hydrochloride DL-EPINEPHRINE HYDROCHLORIDE 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol hydrochloride rs-epinephrine hcl Racepinephrine/Adrenaline HCL (+/-)-EPINEPHRINE HYDROCHLORIDE (+/-)-adrenaline hydrochloride (-)-3,4-DIHYDROXY-α-((METHYLAMINO)METHYL)BENZYL ALCOHOL HYDROCHLORIDE (+/-)-ADRENALIN HYDROCHLORIDE MFCD00050562 4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol hydrochloride (1:1) epinephrine HCl RAC EPINEPHRINE HCL (R/S)-adrenaline hydrochloride Benzyl alcohol, 3,4-dihydroxy-α-((methylamino)methyl)-, hydrochloride, (-)- l-1-(3,4-dihydroxyphenyl)-2-methylamino-1-ethanol hydrochloride 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, hydrochloride (1:1) UNII:336096P2WE EINECS 206-346-0 4-[1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol hydrochloride (1:1) Diaceton-alpha-D-mannofuranose Epinephrine Hydrochloride

Density	1.283 g/cm3
Boiling Point	413.1ºC at 760 mmHg
Molecular Formula	C₉H₁₄ClNO₃
Molecular Weight	219.665
Flash Point	207.9ºC
Exact Mass	219.066223
PSA	72.72000
LogP	1.54350
Stability	Stable, but light sensitive. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.
Water Solubility	H2O: >50 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO3330000

CHEMICAL NAME :: Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 329-63-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H13-N-O3.Cl-H

MOLECULAR WEIGHT :: 219.69

WISWESSER LINE NOTATION :: QR BQ DYQ1M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,1705,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,1705,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,1705,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,369,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,108,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3132 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 207 (estimated) No. of Female Employees: 69 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H311-H315-H319-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338-P312
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R24/25
Safety Phrases	S26-S36/37-S45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	DO3330000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2922509090

Precursor 1
87697-27-6
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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