Name | nogalamycin |
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Synonyms |
antibiotic205t3
nogalomycin NOGALAMYCIN NOGALAMYCIN,STREPTOMYCES NOGALATER |
Description | Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer[1][2]. |
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Related Catalog | |
Target |
RNA Synthesis[2] |
In Vitro | Nogalamycin (0-10 μg/ml; 2 hours) exhibits lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml[1]. Cell Cytotoxicity Assay Cell Line: CHO, L1210 and B16 cells[1] Concentration: 0-10 μg/ml Incubation Time: 2 hours Result: Exhibited lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml. |
In Vivo | Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3]. Animal Model: Rats[1] Dosage: 0-1000 mug/kg Administration: IP Result: Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg. |
References |
Density | 1.49g/cm3 |
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Boiling Point | 899.9ºC at 760mmHg |
Molecular Formula | C39H49NO16 |
Molecular Weight | 787.80 |
Flash Point | 498.1ºC |
Exact Mass | 787.30500 |
PSA | 229.44000 |
LogP | 1.13800 |
Vapour Pressure | 7.49E-35mmHg at 25°C |
Index of Refraction | 1.648 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
Symbol |
GHS07, GHS08 |
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Signal Word | Danger |
Hazard Statements | H302-H312-H332-H350-H360 |
Precautionary Statements | P201-P280-P308 + P313 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | 45-46-61-20/21/22 |
Safety Phrases | 53-22-36/37/39-45 |
RIDADR | NONH for all modes of transport |
RTECS | RA4550000 |